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KMID : 0878220190310020022
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Journal of Sasang Constitutional Medicine
2019 Volume.31 No. 2 p.22 ~ p.30
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Clinical Study on Nonalcoholic Fatty Liver Disease Related Factors: Tumor Marker, Heart Rate Variability, Sasang Constitution
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Gwak Si-Ra
Shen Lei
Park Soo-Jung
Kwon Young-Mi
Joo Jong-Cheon
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Abstract
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Objectives : The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD).
Methods : The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed.
Results : Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control.
Conclusions : The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.
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KEYWORD
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nonalcoholic fatty liver disease, related factor, alpha-feto protein, heart rate variability, Sasang constitution, metabolic syndrome
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